Research Paper

2021

Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice.
Nojiri S, Tsuchiya A, Natsui K, Takeuchi S, Watanabe T, Kojima Y, Watanabe Y, Kamimura H, Ogawa M, Motegi S, Iwasawa T, Sato T, Kumagai M, Ishii Y, Kitayama T, Li YT, Ouchi Y, Shimbo T, Takamura M, Tamai K, Terai S. Inflamm Regen. 2021 Sep 27;41(1):28. doi: 10.1186/s41232-021-00177-4

2020

High-mobility group box 1 fragment suppresses adverse post-infarction remodeling by recruiting PDGFRalpha-positive bone marrow cells.
Goto T, Miyagawa S, Tamai K, Matsuura R, Kido T, Kuratani T, Shimamura K, Sakaniwa R, Harada A, Sawa Y. PLoS One. 2020 Apr 10;15(4):e0230392. doi: 10.1371/journal.pone.0230392. eCollection 2020.

2018

The administration of high-mobility group box 1 fragment prevents deterioration of cardiac performance by enhancement of bone marrow mesenchymal stem cell homing in the delta-sarcoglycan-deficient hamster.
Kido T, Miyagawa S, Goto T, Tamai K, Ueno T, Toda K, Kuratani T, Sawa Y.
PLoS One. 2018 Dec 5;13(12):e0202838.

2016

Stem Cell Therapy for Epidermolysis Bullosa-Does It Work?
Tamai K, Uitto J.
J Invest Dermatol. 2016 Nov;136(11):2119-2121.

2015

Endogenous mesenchymal stromal cells in bone marrow are required to preserve muscle function in mdx mice.
Fujita R, Tamai K, Aikawa E, Nimura K, Ishino S, Kikuchi Y, Kaneda Y.
Stem Cells. 2015 Mar;33(3):962-75.
Transplanted bone marrow-derived circulating PDGFRα+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft.
Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath JA, Uitto J, Ishii M, Iizuka H, Kaneda Y.
J Immunol. 2015 Feb 15;194(4):1996-2003.
Systemic high-mobility group box 1 administration suppresses skin inflammation by inducing an accumulation of PDGFRα(+) mesenchymal cells from bone marrow.
Aikawa E, Fujita R, Kikuchi Y, Kaneda Y, Tamai K.
Sci Rep. 2015 Jun 5;5:11008.

2011

PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia.
Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath JA, Uitto J, Kaneda Y.
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6609-14.