Through collaborative research with the Graduate School of Medicine, Osaka University, we have found that some in vivo substances released from damaged tissues had physiological activities of mobilizing bone marrow mesenchymal stem cells into peripheral blood circulation and to accumulate them in damaged tissues in order to promote tissue regeneration in the body. We discovered such an in vivo tissue regeneration enhancing mechanism for the first time and have secured the intellectual property of these research results.
【Mechanism for promoting tissue regeneration in vivo】
1. Injury or illness causes large scale tissue damage with necrosis.
2. Some in vivo substances are released from the necrotic tissue
3. These in vivo substances circulate in peripheral blood as SOS signals from damaged tissue
4. The SOS signal reaches the bone marrow, and the residing mesenchymal stem cells are activated and released from the bone marrow into the blood stream
5. The mesenchymal stem cells are then delivered to the damaged tissue via peripheral blood circulation
6. The mesenchymal stem cells delivered and accumulated in the damaged
If we can control this innate tissue regeneration mechanism that responds to certain signals from damaged tissues by administering some artificial compound, we can create a novel medicine that has the same therapeutic effect as regenerative medicine by simple medication.
Through intensive collaborative research with Osaka University, we have succeeded in identifying in vivo regeneration-inducing factors, in establishing a large-scale production method for them, and in demonstrating their therapeutic effects in multiple disease-model efficacy tests.
In order to put those compounds to practical use as the world’s first Regeneration-inducing Medicines, we are currently pursuing active research and clinical development on these drugs.